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Background:

Several studies suggest links between cancer and tricyclic antidepressant use.

Methods:

A case–control study using the General Practice Research Database examined whether previous tricyclic usage was associated with reduced incidence of brain (with glioma as a sub-category), breast, colorectal, lung and prostate cancers. Conditional logistic regression adjusted for age, gender, general practice, depression, smoking, body mass index, alcohol use and non-steroidal anti-inflammatory drug use.

Results:

A total of 31 953 cancers were identified, each matched with up to two controls. We found a statistically significant reduction in tricyclic prescriptions compared with controls in glioma (odds ratio (OR)= 0.59, 95% confidence interval (CI)= 0.42–0.81) and colorectal cancer patients (OR= 0.84, CI= 0.75–0.94). These effects were dose-dependent (P-values for trend, glioma= 0.0005, colorectal= 0.001) and …