作者
Angel YS Wong, Brian MacKenna, Caroline E Morton, Anna Schultze, Alex J Walker, Krishnan Bhaskaran, Jeremy P Brown, Christopher T Rentsch, Elizabeth Williamson, Henry Drysdale, Richard Croker, Seb Bacon, William Hulme, Chris Bates, Helen J Curtis, Amir Mehrkar, David Evans, Peter Inglesby, Jonathan Cockburn, Helen I McDonald, Laurie Tomlinson, Rohini Mathur, Kevin Wing, Harriet Forbes, Rosalind M Eggo, John Parry, Frank Hester, Sam Harper, Stephen JW Evans, Liam Smeeth, Ian J Douglas, Ben Goldacre
发表日期
2021/1/21
期刊
Annals of the Rheumatic Diseases
出版商
BMJ Publishing Group Ltd
简介
Objectives
To assess the association between routinely prescribed non-steroidal anti-inflammatory drugs (NSAIDs) and deaths from COVID-19 using OpenSAFELY, a secure analytical platform.
Methods
We conducted two cohort studies from 1 March to 14 June 2020. Working on behalf of National Health Service England, we used routine clinical data in England linked to death data. In study 1, we identified people with an NSAID prescription in the last 3 years from the general population. In study 2, we identified people with rheumatoid arthritis/osteoarthritis. We defined exposure as current NSAID prescription within the 4 months before 1 March 2020. We used Cox regression to estimate HRs for COVID-19 related death in people currently prescribed NSAIDs, compared with those not currently prescribed NSAIDs, accounting for age, sex, comorbidities, other medications and geographical region.
Results
In study 1, we …
学术搜索中的文章
AYS Wong, B MacKenna, CE Morton, A Schultze… - Annals of the rheumatic diseases, 2021
OpenSAFELY Collaborative, AYS Wong, B MacKenna… - medRxiv, 2020