作者
Scott W Menzies, Juergen Kreusch, Karen Byth, Maria A Pizzichetta, Ashfaq Marghoob, Ralph Braun, Josep Malvehy, Susana Puig, Giuseppe Argenziano, Iris Zalaudek, Harold S Rabinovitz, Margaret Oliviero, Horacio Cabo, Verena Ahlgrimm-Siess, Michelle Avramidis, Pascale Guitera, H Peter Soyer, Giovanni Ghigliotti, Masaru Tanaka, Ana M Perusquia, Gianluca Pagnanelli, Riccardo Bono, Luc Thomas, Giovanni Pellacani, David Langford, Domenico Piccolo, Karin Terstappen, Ignazio Stanganelli, Alex Llambrich, Robert Johr
发表日期
2008/9/15
期刊
Archives of dermatology
卷号
144
期号
9
页码范围
1120-1127
出版商
American Medical Association
简介
Objective
To determine the predictive dermoscopic features of amelanotic and hypomelanotic melanoma.
Design
A total of 105 melanomas (median Breslow thickness, 0.76 mm), 170 benign melanocytic lesions, and 222 nonmelanocytic lesions lacking significant pigment (amelanotic, partially pigmented, and light colored) were imaged using glass-plate dermoscopy devices and scored for 99 dermoscopic features. Diagnostic models were derived from and tested on independent randomly selected lesions.
Setting
Predominantly hospital-based clinics from 5 continents.
Main Outcome Measures
Sensitivity, specificity, and odds ratios for individual features and models for the diagnosis of melanoma and malignancy.
Results
The most significant negative predictors of melanoma were having multiple (>3) milialike cysts (odds ratio, 0.09; 95% confidence interval, 0.01-0.64), comma vessels with a regular distribution (0.10; 0 …
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