作者
Sara Stinca, Maria Andersson, Sandra Weibel, Isabelle Herter-Aeberli, Ralph Fingerhut, Sueppong Gowachirapant, Sonja Y Hess, Nidhi Jaiswal, Tomislav Jukić, Zvonko Kusic, Ngoako Solomon Mabapa, Ashwini Kumar Nepal, Teofilo OL San Luis, Jia Qing Zhen, Michael Bruce Zimmermann
发表日期
2017/1/1
期刊
The Journal of Clinical Endocrinology & Metabolism
卷号
102
期号
1
页码范围
23-32
出版商
Endocrine Society
简介
Context
Thyroglobulin (Tg) could be a sensitive biomarker of iodine nutrition in pregnant women (PW). A dried blood spot (DBS) assay would simplify collection and transport in field studies.
Objectives
Our aims were to (1) establish and test a reference range for DBS-Tg in PW; (2) determine whether co-measurement of Tg antibodies (Abs) is necessary to define population iodine status.
Design, Setting, and Participants
Standardized cross-sectional studies of 3870 PW from 11 countries. For the DBS-Tg reference range, we included TgAb-negative PW (n = 599) from 3 countries with sufficient iodine intake.
Main Outcome Measures
We measured the urinary iodine concentration and DBS thyroid-stimulating hormone, total thyroxin, Tg, and TgAb.
Results
In the reference population, the median DBS-Tg was 9.2 μg/L …
学术搜索中的文章
S Stinca, M Andersson, S Weibel, I Herter-Aeberli… - The Journal of Clinical Endocrinology & Metabolism, 2017