作者
Jean-Pierre Gillet, Thomas Efferth, José Remacle
发表日期
2007/6/1
来源
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer
卷号
1775
期号
2
页码范围
237-262
出版商
Elsevier
简介
A key issue in the treatment of many cancers is the development of resistance to chemotherapeutic drugs. Resistance mechanisms are numerous and complex. One of them is mediated by the overexpression of ATP-binding cassette (ABC) transporters able to efflux drugs out of the tumor cell. The last two decades have seen notable growth of knowledge concerning the involvement of ABC transporters in resistance to chemotherapy. This review emphasizes these transporters, their clinical relevance and the diagnostic methods and strategies to circumvent multidrug resistance (MDR) mediated by ABC transporters.
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JP Gillet, T Efferth, J Remacle - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2007