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An ideal 3D-scaffold for tissue regeneration should have similarity to native ECM in terms of both chemical composition and physical nanostructure. Recently, nanostructured biomaterials having physical nanofeatures such as nanocrystals, nanofibers nanosurfaces, nanocomposites, etc. gained much interest in regenerative medicine. This is mainly because of their resemblance of physical nanofeatures to natural extra cellular matrices. This review mainly focuses on nanocrystalline bioresrobable bioceramic scaffolds and nanofibrous polymeric scaffolds for tissue regeneration. Fabrication of porous bioceramics based on HA and other calcium phosphates with interconnected pore structure can be done by the replication of polymer foam. The advantage of this technique is the control over porosity, pore geometry and pore size of the fabricated scaffolds. Therefore, the first part of the review focused on porous …