作者
Emma L Beckett, Richard L Stevens, Andrew G Jarnicki, Richard Y Kim, Irwan Hanish, Nicole G Hansbro, Andrew Deane, Simon Keely, Jay C Horvat, Ming Yang, Brian G Oliver, Nico Van Rooijen, Mark D Inman, Roberto Adachi, Roy J Soberman, Sahar Hamadi, Peter A Wark, Paul S Foster, Philip M Hansbro
发表日期
2013/3/1
期刊
Journal of Allergy and Clinical Immunology
卷号
131
期号
3
页码范围
752-762. e7
出版商
Mosby
简介
BACKGROUND
Cigarette smoke–induced chronic obstructive pulmonary disease (COPD) is a life-threatening inflammatory disorder of the lung. The development of effective therapies for COPD has been hampered by the lack of an animal model that mimics the human disease in a short timeframe.
OBJECTIVES
We sought to create an early-onset mouse model of cigarette smoke–induced COPD that develops the hallmark features of the human condition in a short time-frame. We also sought to use this model to better understand pathogenesis and the roles of macrophages and mast cells (MCs) in patients with COPD.
METHODS
Tightly controlled amounts of cigarette smoke were delivered to the airways of mice, and the development of the pathologic features of COPD was assessed. The roles of macrophages and MC tryptase in pathogenesis were evaluated by using depletion and in vitro studies and MC …
学术搜索中的文章
EL Beckett, RL Stevens, AG Jarnicki, RY Kim, I Hanish… - Journal of Allergy and Clinical Immunology, 2013