作者
Katja Beesdo, Jennifer YF Lau, Amanda E Guyer, Erin B McClure-Tone, Christopher S Monk, Eric E Nelson, Stephen J Fromm, Michelle A Goldwin, Hans-Ulrich Wittchen, Ellen Leibenluft, Monique Ernst, Daniel S Pine
发表日期
2009/3/1
期刊
Archives of general psychiatry
卷号
66
期号
3
页码范围
275-285
出版商
American Medical Association
简介
Context
Few studies directly compare amygdala function in depressive and anxiety disorders. Data from longitudinal research emphasize the need for such studies in adolescents.
Objective
To compare amygdala response to varying attention and emotion conditions among adolescents with major depressive disorder (MDD) or anxiety disorders, relative to adolescents with no psychopathology.
Design
Case-control study.
Setting
Government clinical research institute.
Participants
Eighty-seven adolescents matched on age, sex, intelligence, and social class: 26 with MDD (14 with and 12 without anxiety disorders), 16 with anxiety disorders but no depression, and 45 without psychopathology.
Main Outcome Measures
Blood oxygen level–dependent signal in the amygdala, measured by means of event-related functional magnetic resonance imaging. During imaging, participants viewed facial expressions (neutral, fearful …
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