作者
Won Jae Lee, Sarah J Roberts-Thomson, Gregory R Monteith
发表日期
2005/11/25
期刊
Biochemical and biophysical research communications
卷号
337
期号
3
页码范围
779-783
出版商
Academic Press
简介
There is evidence to suggest that plasma membrane Ca2+-ATPase (PMCA) isoforms are important mediators sssof mammary gland physiology. PMCA2 in particular is upregulated extensively during lactation. Expression of other isoforms such as PMCA4 may influence mammary gland epithelial cell proliferation and aberrant regulation of PMCA isoform expression may lead or contribute to mammary gland pathophysiology in the form of breast cancers. To explore whether PMCA2 and PMCA4 expression may be deregulated in breast cancer, we compared mRNA expression of these PMCA isoforms in tumorigenic and non-tumorigenic human breast epithelial cell lines using real time RT-PCR. PMCA2 mRNA has a higher level of expression in some breast cancer cell lines and is overexpressed more than 100-fold in ZR-75-1 cells, compared to non-tumorigenic 184B5 cells. Although differences in PMCA4 mRNA …
引用总数
学术搜索中的文章
WJ Lee, SJ Roberts-Thomson, GR Monteith - Biochemical and biophysical research communications, 2005