作者
Iman Osman, Howard I Scher, Marija Drobnjak, David Verbel, Michael Morris, David Agus, Jeffrey S Ross, Carlos Cordon-Cardo
发表日期
2001/9/1
期刊
Clinical Cancer Research
卷号
7
期号
9
页码范围
2643-2647
出版商
American Association for Cancer Research
简介
Purpose: Amplification of HER-2/neu gene and overexpression of its encoded product, the p185neu (HER-2/neu) tyrosine kinase membrane receptor, have been associated with tumor progression in certain neoplasms. We conducted this study to investigate patterns of HER-2/neu protein expression in prostate cancer, analyzing different points in the natural and treated history of the disease.
Experimental Design: Radical prostatectomy cases (83) and 20 metastatic lesions were studied for the association between HER-2/neu protein overexpression detected by immunohistochemistry and clinicopathological parameters, including time to prostate-specific antigen (PSA) relapse.
Results: HER-2/neu protein overexpression, defined as complete membrane staining in >10% of tumor cells using the Food and Drug Administration-approved Dako kit, was found in 9 of 45 (20%) of evaluable …
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I Osman, HI Scher, M Drobnjak, D Verbel, M Morris… - Clinical Cancer Research, 2001