作者
C Arden Pope III, Aruni Bhatnagar, James P McCracken, Wesley Abplanalp, Daniel J Conklin, Timothy O’Toole
发表日期
2016/11/11
期刊
Circulation research
卷号
119
期号
11
页码范围
1204-1214
出版商
Lippincott Williams & Wilkins
简介
Rationale:
Epidemiological evidence indicates that exposures to fine particulate matter air pollution (PM2.5) contribute to global burden of disease, primarily as a result of increased risk of cardiovascular morbidity and mortality. However, mechanisms by which PM2.5 exposure induces cardiovascular injury remain unclear. PM2.5-induced endothelial dysfunction and systemic inflammation have been implicated, but direct evidence is lacking.
Objective:
To examine whether acute exposure to PM2.5 is associated with endothelial injury and systemic inflammation.
Methods and Results:
Blood was collected from healthy, nonsmoking, young adults during 3 study periods that included episodes of elevated PM2.5 levels. Microparticles and immune cells in blood were measured by flow cytometry, and plasma cytokine/growth factors were measured using multiplexing laser beads. PM2.5 exposure was associated with the …
学术搜索中的文章
CA Pope III, A Bhatnagar, JP McCracken, W Abplanalp… - Circulation research, 2016