作者
Mayte Sánchez van Kammen, Erik Lindgren, Suzanne M Silvis, Sini Hiltunen, Mirjam Rachel Heldner, Fabiola Serrano, Johan Zelano, Susanna M Zuurbier, Maryam Mansour, Diana Aguiar de Sousa, Patrícia Canhão, Saleem Al-Asady, Esme Ekizoglu, Petra Redfors, Nilufer Yesilot, Masoud Ghiasian, Miguel A Barboza, Valentina Arnao, Paolo Aridon, Martin NM Punter, José M Ferro, Antonio Arauz, Turgut Tatlisumak, Marcel Arnold, Jukka Putaala, Katarina Jood, Jonathan M Coutinho
发表日期
2020/9/22
期刊
Neurology
卷号
95
期号
12
页码范围
e1716-e1723
出版商
Lippincott Williams & Wilkins
简介
Objective
To examine the incidence, characteristics, treatment, and predictors of late seizures (LS) after cerebral venous thrombosis (CVT), we described these features in a registry of 1,127 patients with CVT.
Methods
We included consecutive adult patients from an international consortium of 12 hospital-based CVT registries. We excluded patients with a history of epilepsy or with <8 days of follow-up. We defined LS as seizures occurring >7 days after diagnosis of CVT. We used multivariable Cox regression to identify predictors of LS.
Results
We included 1,127 patients with CVT. During a median follow-up of 2.0 years (interquartile range [IQR] 1.0–6.3), 123 patients (11%) experienced ≥1 LS (incidence rate for first LS 30 per 1,000 person-years, 95% confidence interval [CI] 25–35). Median time to first LS was 5 months (IQR 1–16 months). Baseline predictors of LS included status epilepticus in the acute phase …
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M Sánchez van Kammen, E Lindgren, SM Silvis… - Neurology, 2020