作者
Jukka Putaala, Nicolas Martinez-Majander, Sahrai Saeed, Nilufer Yesilot, Pekka Jäkälä, Ossi Nerg, Georgios Tsivgoulis, Heikki Numminen, Daniel Gordin, Bettina von Sarnowski, Ulrike Waje-Andreassen, Pauli Ylikotila, Risto O Roine, Marialuisa Zedde, Juha Huhtakangas, Catarina Fonseca, Petra Redfors, Frank-Erik de Leeuw, Alessandro Pezzini, Janika Kõrv, Siim Schneider, Christian Tanislav, Christian Enzinger, Dalius Jatuzis, Bob Siegerink, Patricia Martínez-Sánchez, Armin J Grau, Frederick Palm, Per-Henrik Groop, Sylvain Lanthier, Hugo Ten Cate, Pirkko Pussinen, Susanna Paju, Juha Sinisalo, Mika Lehto, Arne Lindgren, José Ferro, Steven Kittner, Franz Fazekas, Eva Gerdts, Turgut Tatlisumak
发表日期
2017/6
期刊
European Stroke Journal
卷号
2
期号
2
页码范围
116-125
出版商
SAGE Publications
简介
Background
Worldwide, about 1.3 million annual ischaemic strokes (IS) occur in adults aged <50 years. Of these early-onset strokes, up to 50% can be regarded as cryptogenic or associated with conditions with poorly documented causality like patent foramen ovale and coagulopathies.
Key hypotheses/aims
(1) Investigate transient triggers and clinical/sub-clinical chronic risk factors associated with cryptogenic IS in the young; (2) use cardiac imaging methods exceeding state-of-the-art to reveal novel sources for embolism; (3) search for covert thrombosis and haemostasis abnormalities; (4) discover new disease pathways using next-generation sequencing and RNA gene expression studies; (5) determine patient prognosis by use of phenotypic and genetic data; and (6) adapt systems medicine approach to investigate complex risk-factor interactions.
Design
Searching for Explanations for Cryptogenic Stroke in the …
学术搜索中的文章
J Putaala, N Martinez-Majander, S Saeed, N Yesilot… - European Stroke Journal, 2017