作者
Erik Lindgren, Suzanne M Silvis, Sini Hiltunen, Mirjam R Heldner, Fabiola Serrano, Michele de Scisco, Johan Zelano, Susanna M Zuurbier, Mayte Sánchez van Kammen, Maryam Mansour, Diana Aguiar de Sousa, Sara Penas, Saleem Al-Asady, Esme Ekizoglu, Petra Redfors, Awet Ahmed, Nilufer Yesilot, Masoud Ghiasian, Miguel A Barboza, Valencia Arnao, Paolo Aridon, Martin NM Punter, José M Ferro, Timothy Kleinig, Antonio Arauz, Turgut Tatlisumak, Marcel Arnold, Jukka Putaala, Jonathan M Coutinho, Katarina Jood
发表日期
2020/9/22
期刊
Neurology
卷号
95
期号
12
页码范围
e1706-e1715
出版商
Lippincott Williams & Wilkins
简介
Objective
To identify characteristics, predictors, and outcomes of acute symptomatic seizures (ASS) in cerebral venous thrombosis (CVT), we investigated 1,281 consecutive adult patients with CVT included from 12 hospitals within the International CVT Consortium.
Methods
We defined ASS as any seizure between symptom onset and 7 days after diagnosis of CVT. We stratified ASS into prediagnosis and solely postdiagnosis ASS. Status epilepticus (SE) was also analyzed separately. We analyzed predictors for ASS and the association between ASS and clinical outcome (modified Rankin Scale) with multivariable logistic regression.
Results
Of 1,281 eligible patients, 441 (34%) had ASS. Baseline predictors for ASS were intracerebral hemorrhage (ICH; adjusted odds ratio [aOR] 4.1, 95% confidence interval [CI] 3.0–5.5), cerebral edema/infarction without ICH (aOR 2.8, 95% CI 2.0–4.0), cortical vein thrombosis (aOR 2 …
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E Lindgren, SM Silvis, S Hiltunen, MR Heldner… - Neurology, 2020