作者
Jian Wu, Yuchen Jiao, Marco Dal Molin, Anirban Maitra, Roeland F De Wilde, Laura D Wood, James R Eshleman, Michael G Goggins, Christopher L Wolfgang, Marcia I Canto, Richard D Schulick, Barish H Edil, Michael A Choti, Volkan Adsay, David S Klimstra, G Johan A Offerhaus, Alison P Klein, Levy Kopelovich, Hannah Carter, Rachel Karchin, Peter J Allen, C Max Schmidt, Yoshiki Naito, Luis A Diaz Jr, Kenneth W Kinzler, Nickolas Papadopoulos, Ralph H Hruban, Bert Vogelstein
发表日期
2011/12/27
期刊
Proceedings of the National Academy of Sciences
卷号
108
期号
52
页码范围
21188-21193
出版商
National Academy of Sciences
简介
More than 2% of adults harbor a pancreatic cyst, a subset of which progresses to invasive lesions with lethal consequences. To assess the genomic landscapes of neoplastic cysts of the pancreas, we determined the exomic sequences of DNA from the neoplastic epithelium of eight surgically resected cysts of each of the major neoplastic cyst types: serous cystadenomas (SCAs), intraductal papillary mucinous neoplasms (IPMNs), mucinous cystic neoplasms (MCNs), and solid pseudopapillary neoplasms (SPNs). SPNs are low-grade malignancies, and IPMNs and MCNs, but not SCAs, have the capacity to progress to cancer. We found that SCAs, IPMNs, MCNs, and SPNs contained 10 ± 4.6, 27 ± 12, 16 ± 7.6, and 2.9 ± 2.1 somatic mutations per tumor, respectively. Among the mutations identified, E3 ubiquitin ligase components were of particular note. Four of the eight SCAs contained mutations of the von Hippel …
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J Wu, Y Jiao, M Dal Molin, A Maitra, RF De Wilde… - Proceedings of the National Academy of Sciences, 2011