作者
Nils R Winter, Ramona Leenings, Jan Ernsting, Kelvin Sarink, Lukas Fisch, Daniel Emden, Julian Blanke, Janik Goltermann, Nils Opel, Carlotta Barkhau, Susanne Meinert, Katharina Dohm, Jonathan Repple, Marco Mauritz, Marius Gruber, Elisabeth J Leehr, Dominik Grotegerd, Ronny Redlich, Andreas Jansen, Igor Nenadic, Markus M Nöthen, Andreas Forstner, Marcella Rietschel, Joachim Groß, Jochen Bauer, Walter Heindel, Till Andlauer, Simon B Eickhoff, Tilo Kircher, Udo Dannlowski, Tim Hahn
发表日期
2022/9/1
期刊
JAMA psychiatry
卷号
79
期号
9
页码范围
879-888
出版商
American Medical Association
简介
Importance
Identifying neurobiological differences between patients with major depressive disorder (MDD) and healthy individuals has been a mainstay of clinical neuroscience for decades. However, recent meta-analyses have raised concerns regarding the replicability and clinical relevance of brain alterations in depression.
Objective
To quantify the upper bounds of univariate effect sizes, estimated predictive utility, and distributional dissimilarity of healthy individuals and those with depression across structural magnetic resonance imaging (MRI), diffusion-tensor imaging, and functional task-based as well as resting-state MRI, and to compare results with an MDD polygenic risk score (PRS) and environmental variables.
Design, Setting, and Participants
This was a cross-sectional, case-control clinical neuroimaging study. Data were part of the Marburg-Münster Affective Disorders Cohort Study. Patients with …
学术搜索中的文章
NR Winter, R Leenings, J Ernsting, K Sarink, L Fisch… - JAMA psychiatry, 2022