作者
Rachel M Brouwer, Marieke Klein, Katrina L Grasby, Hugo G Schnack, Neda Jahanshad, Jalmar Teeuw, Sophia I Thomopoulos, Emma Sprooten, Carol E Franz, Nitin Gogtay, William S Kremen, Matthew S Panizzon, Loes M Olde Loohuis, Christopher D Whelan, Moji Aghajani, Clara Alloza, Dag Alnæs, Eric Artiges, Rosa Ayesa-Arriola, Gareth J Barker, Mark E Bastin, Elisabet Blok, Erlend Bøen, Isabella A Breukelaar, Joanna K Bright, Elizabeth EL Buimer, Robin Bülow, Dara M Cannon, Simone Ciufolini, Nicolas A Crossley, Christienne G Damatac, Paola Dazzan, Casper L De Mol, Sonja MC de Zwarte, Sylvane Desrivières, Covadonga M Díaz-Caneja, Nhat Trung Doan, Katharina Dohm, Juliane H Fröhner, Janik Goltermann, Antoine Grigis, Dominik Grotegerd, Laura KM Han, Mathew A Harris, Catharina A Hartman, Sarah J Heany, Walter Heindel, Dirk J Heslenfeld, Sarah Hohmann, Bernd Ittermann, Philip R Jansen, Joost Janssen, Tianye Jia, Jiyang Jiang, Christiane Jockwitz, Temmuz Karali, Daniel Keeser, Martijn GJC Koevoets, Rhoshel K Lenroot, Berend Malchow, René CW Mandl, Vicente Medel, Susanne Meinert, Catherine A Morgan, Thomas W Mühleisen, Leila Nabulsi, Nils Opel, Víctor Ortiz-García de la Foz, Bronwyn J Overs, Marie-Laure Paillère Martinot, Ronny Redlich, Tiago Reis Marques, Jonathan Repple, Gloria Roberts, Gennady V Roshchupkin, Nikita Setiaman, Elena Shumskaya, Frederike Stein, Gustavo Sudre, Shun Takahashi, Anbupalam Thalamuthu, Diana Tordesillas-Gutiérrez, Aad Van der Lugt, Neeltje EM Van Haren, Joanna M Wardlaw, Wei Wen, Henk-Jan Westeneng, Katharina Wittfeld, Alyssa H Zhu, Andre Zugman, Nicola J Armstrong, Gaia Bonfiglio, Janita Bralten, Shareefa Dalvie, Gail Davies, Marta Di Forti, Linda Ding, Gary Donohoe, Andreas J Forstner, Javier Gonzalez-Peñas, Joao POFT Guimaraes, Georg Homuth, Jouke-Jan Hottenga, Maria J Knol, John BJ Kwok, Stephanie Le Hellard, Karen A Mather, Yuri Milaneschi, Derek W Morris, Markus M Nöthen, Sergi Papiol, Marcella Rietschel, Marcos L Santoro, Vidar M Steen, Jason L Stein, Fabian Streit, Rick M Tankard, Alexander Teumer, Dennis van ‘t Ent, Dennis Van der Meer, Kristel R Van Eijk, Evangelos Vassos, Javier Vázquez-Bourgon, Stephanie H Witt, IMAGEN Consortium Brühl Rüdiger 158 Papadopoulos Orfanos Dimitri 159 Paus Tomáš 160 161 Millenet Sabina 162, Hieab HH Adams, Ingrid Agartz, David Ames, Katrin Amunts, Ole A Andreassen, Celso Arango, Tobias Banaschewski, Bernhard T Baune, Sintia I Belangero, Arun LW Bokde, Dorret I Boomsma, Rodrigo A Bressan, Henry Brodaty, Jan K Buitelaar, Wiepke Cahn, Svenja Caspers, Sven Cichon, Benedicto Crespo-Facorro, Simon R Cox, Udo Dannlowski, Torbjørn Elvsåshagen, Thomas Espeseth, Peter G Falkai, Simon E Fisher, Herta Flor
发表日期
2022/4
期刊
Nature neuroscience
卷号
25
期号
4
页码范围
421-432
出版商
Nature Publishing Group US
简介
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes …
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RM Brouwer, M Klein, KL Grasby, HG Schnack… - Nature neuroscience, 2022