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Arabidopsis (Arabidopsis thaliana) hexokinase (AtHXK1) encodes a dual-function enzyme that mediates sugar sensing in addition to its involvement in hexose phosphorylation activity, thereby coordinating sugar availability with plant physiology and development (Moore et al., 2003; Rolland et al., 2006). Sugars such as Glc are essential metabolic nutrients and structural components and are important regulatory molecules that control gene expression, metabolism, physiology, the cell cycle, and development in prokaryotes and eukaryotes. Hexokinase (HXK), which catalyzes the essential step of Glc phosphorylation, is an evolutionarily conserved Glc sensor (Wilson, 2003; Rolland et al., 2006; Karve et al., 2010). Most studies of HXK in plants have involved AtHXK1. The AtHXK1 loss-of-function mutant glucose-insensitive2 (gin2) was isolated through a mutant screen based on a high-Glc (6%) repression assay, in …