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Dichloroacetate (DCA) and trichloroacetate (TCA) are drinking-water chlorination by-products previously found to induce oxidative stress (OS) in hepatic tissues of B6C3F1 male mice. To assess the effects of mixtures of the compounds on OS, groups of male B6C3F1 mice were treated daily by gavage with DCA at doses of 7.5, 15, or 30 mg/kg/d, TCA at doses of 12.5, 25, or 50 mg/kg/d, and 3 mixtures of DCA and TCA (Mix I, Mix II, and Mix III), for 13 wk. The concentrations of the compounds in Mix I, Mix II, and Mix III corresponded to those producing approximately 15, 25, and 35%, respectively, of maximal induction of OS by individual compounds. Livers were assayed for production of superoxide anion (SA), lipid peroxidation (LP), and DNA single-strand breaks (SSB). DCA, TCA, and the mixtures produced dose-dependent increases in the three tested biomarkers. Mix I and II effects on the three biomarkers, and Mix …