作者
R Rachana, Harshit Devtalla, Karishma Rana, Siva Prasad Panda, Arushi Agrawal, Shreya Kadyan, Divya Jindal, Pranav Pancham, Deepshikha Yadav, Niraj Kumar Jha, Saurabh Kumar Jha, Vivek Gupta, Manisha Singh
发表日期
2024/1/1
来源
Chemical biology & drug design
简介
Schizophrenia is a severe psychological disorder in which reality is interpreted abnormally by the patient. The symptoms of the disease include delusions and hallucinations, associated with extremely disordered behavior and thinking, which may affect the daily lives of the patients. Advancements in technology have led to understanding the dynamics of the disease and the identification of the underlying causes. Multiple investigations prove that it is regulated genetically, and epigenetically, and is affected by environmental factors. The molecular and neural pathways linked to the regulation of schizophrenia have been extensively studied. Over 180 Schizophrenic risk loci have now been recognized due to several genome-wide association studies (GWAS). It has been observed that multiple transcription factors (TF) binding-disrupting single nucleotide polymorphisms (SNPs) have been related to gene expression …
学术搜索中的文章