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The prevalence and distribution of Central nervous system (CNS) disorders are increasing globally until 2021. It was estimated that 55 million people worldwide were already affected by dementia or Alzheimer's disease (AD). As a result, effective bioactive chemicals are in high demand. Withania somnifera is an Indian herb that has been used to treat a variety of neurological disorders. In our study, we have computationally evaluated the efficacy of Withania somnifera for their neuroprotective targets against AD. Thereafter, they have been formulated for the oil-in-water nano-emulsion system and optimized to attain the nanometric size range. Subsequently, Withania somnifera nanoemulsions were developed by selecting Linseed oil, Tween 20, and Ethanol as oil, surfactant, and co-surfactant respectively with an aqueous titration method. The characterization results exhibited the nanometric size range of the …