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The Areal parts of Adansonia digitata were successively extracted by gradient solvents. The resulting extracts were submitted to bioassay in order to uncover their biological potential. The antiviral activity indicated significant activities: adenovirus type-7 56.6%(MeOH extract) and 66.6%(water extract) while rotavirus Wa strain 63.3% and 70% and coxsackievirus B4 70% titre reduction, while the HepG2 cytotoxicity (IC50 19.3 µg/ml vs 24.46 µg/ml for doxorubicin), analgesic (82.5% vs 79.6% for standard aspirin), antioxidant (38.3 μg/ml vs 4.80 μg/ml for vitamin C) as well as the antiinflammatory (61.5% vs 59.5% for indomethacin) indicated promising activities. Repeated chromatographic columns for these extracts afforded nine chemical compounds. Spectral analysis of these compounds using UV, MS and NMR confirmed the presence of several flavonoids: apigenin, luteolin, Genkwanin, Luteolin-7-O-galactoside, Chrysoeriol-7-O-glucoside and Luteolin-7-O-glucoside. In addition, α-amyrin palmitate, Ursolic acid and Ursolic acid derivative [24-(Trans) Ferulyl) Oxy-3-Hydroxy-Urs-12-En-28-Oic acid] were obtained for the first time from the plant. Total plant flavonoids (3.73 mg/100 mg leaves extract and 1.491 mg/100 mg fruit pulp) and Vit C content (9.33 mg/100g leaves extract and 0.8 mg/100g seed extract) were also determined.