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In the present study human norovirus genogroups I and II (GGI and GGII), Hepatitis E virus (HEV) and human and animal rotaviruses (Wa strain and simian rotavirus), were exposed to different chlorine concentrations in inoculated Nile water and drinking water samples. In raw water samples inoculated separately with viruses before autoclaving, the chlorine dose 5mg/l for 15 min was sufficient to remove 1 log from the 10 initial doses of norovirus GGI and GGII and HEV, while sample inoculated after autoclaving, the chlorine dose 5mg/l for 15 min was sufficient to remove 2 log from the initial doses of norovirus GGI and GGII and HEV. 10 While in drinking water samples, the chlorine dose 3 mg/l for 15 min was sufficient to remove 4 log from the 10 initial dose of norovirus GGI and GGII and HEV. When we increased the chlorine dose to 4 mg/l, 6 log10 reduction of norovirus GGI while 7 log reduction from norovirus GGII and 6 log reduction of HEV was