作者
Andrea T White, Alan R Light, Ronald W Hughen, Lucinda Bateman, Thomas B Martins, Harry R Hill, Kathleen C Light
发表日期
2010/7
期刊
Psychophysiology
卷号
47
期号
4
页码范围
615-624
出版商
Blackwell Publishing Inc
简介
Chronic fatigue syndrome (CFS) patients often report symptom flare (SF) for >24 h after moderate exercise (post‐ex). We hypothesized that SF is linked to increases in circulating cytokines and CD40 Ligand (CD40L). In 19 CFS patients and 17 controls, mental and physical fatigue and pain symptom ratings were obtained together with serum for 11 cytokines and CD40L before and at 0.5, 8, 24, and 48 h post‐ex. Before exercise, CFS had lower CD40L (p<.05) but similar cytokines versus controls. In subgroups based on SF at 48 h, high SF patients (n=11) increased in IL‐1β, IL‐12, IL‐6, IL‐8, IL‐10, and IL‐13 (p<.05) 8 h post‐ex. Low SF patients (n=8) showed post‐ex decreases in IL‐10, IL‐13, and CD40L, and controls decreased in IL‐10, CD40L, and TNFα (p<.05). Thus, in CFS, cytokine activity may vary directly with SF, which may explain prior inconsistent findings.
引用总数
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