作者
Jae-Seon So, Min-Kyung Song, Ho-Keun Kwon, Choong-Gu Lee, Chang-Suk Chae, Anupama Sahoo, Arijita Jash, Sung Haeng Lee, Zee Yong Park, Sin-Hyeog Im
发表日期
2011/2/14
期刊
Life sciences
卷号
88
期号
7-8
页码范围
358-366
出版商
Pergamon
简介
AIMS
We previously reported that Lactobacillus casei (L. casei) has beneficial effects in experimental rheumatoid arthritis (RA) by suppressing inflammatory immune responses. The major purpose of this study was to evaluate therapeutic effects of L. casei on pathological responses in experimental rodent model of osteoarthritis (OA).
MAIN METHODS
Experimental OA was induced by intra-articular injection of monosodium iodoacetate (MIA) in Wistar rats. L. casei alone or together with type II collagen (CII) and glucosamine (Gln) was orally administered into OA rats. The pathophysiological aspects of OA were investigated by analyzing mechanical hyperalgesia and histology of articular tissues. Expression of inflammatory molecules was analyzed in CD4+ T cells, synovial fibroblasts, and chondrocytes by quantitative real-time PCR.
KEY FINDINGS
Oral administration of L. casei together with CII and Gln more …
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