作者
Carolyn S Calfee, Kevin L Delucchi, Pratik Sinha, Michael A Matthay, Jonathan Hackett, Manu Shankar-Hari, Cliona McDowell, John G Laffey, Cecilia M O'Kane, Daniel F McAuley, Andrew J Johnston, Archana Paikray, Cat Yates, Petra Polgarova, Esther Price, Amy McInerney, Katarzyna Zamoscik, Ged Dempsey, Colette Seasman, Lynn Gilfeather, Noel Hemmings, Sinead O'Kane, Paul Johnston, Lukas Pokorny, Chris Nutt, Orla O'Neill, Prashast Prashast, Chris Smalley, Reni Jacob, James O'Rourke, Syed Farjad Sultan, Carole Schilling, Gavin D Perkins, Teresa Melody, Keith Couper, Ron Daniels, Fang Gao, Julian Hull, Timothy Gould, Matthew Thomas, Katie Sweet, Dorothy Breen, Emer Neau, Willis J Peel, Catherine Jardine, Paul Jefferson, Stephen E Wright, Kayla Harris, Sarah Hierons, John Laffey, Veronica McInerney, Luigi Camporota, Katie Lei, Sundeep Kaul, Molly Chibvuri, Andrew Gratrix, Rachael Bennett, Victoria Martinson, Lisa Sleight, Neil Smith, Philip A Hopkins, Daniel Hadfield, Sarah Casboult, Fiona Wade-Smith, Julie Dawson, Clare Mellis, Clair Harris, Georgina Parsons, Sinead Helyar, Andrew R Bodenham, Stuart Elliot, Zoe Beardow, Sian Birch, Brian Marsh, Teresa Martin, Akesh Dhrampal, Melissa Rosbergen, Stephen Webb, Fiona Bottrill, Henrik Reschreiter, Helena Barcraft-Barnes, Julie Camsooksai, Andrew Johnston, Aisling Clarkson, Conor Bentley, Lauren Cooper, Yongyan Qui, Natalie Mitchell, Ronald Carrera, Arlo Whitehouse, Christopher M Danbury, Nicola Jacques, Abby Brown, David Rogerson, Craig Morris, Timothy Walsh, Mike Gillies, Grant Price, Kallirroi Kefala, Neil Young, David Hope, Corrienne McCulloch, Jean Antonelli, Pam Ramsay, Kirsty Everingham, Louise Boardman, Heidi Dawson, Fiona Pollock, Joanne Thompson, Ingeborg D Welters, Lee Poole, Peter Hampshire, Alison Hall, Karen Williams, Anna Walker, Laura Youds, Samantha Hendry, Victoria Waugh, Julie Patrick-Heselton, David Shaw, Irfan Chaudry, Jacqueline Baldwin, Stephen Drage, Laura Ortiz-Ruiz de Gordoa, Daniel McAuley, Leona Bannon, Vanessa Quinn, Lia McNamee, Griania White, Maurizio Cecconi, Johannes Mellinghoff, Donal Ryan, Alistair Nichol, Banwari Agarwal, Paula Meale, Sarah James, Kulwant Dhadwal, Daniel Martin, Agnieszka Walecka, Stephen Ward, John Trinder, Samantha Hagan, Janice Montgomery, Catherine Leonard, Elizabeth Lemon, Tom Trinick, Murthy Buddhavarapu, Geraldine Ward, Christopher Bassford, Alan Davidson
发表日期
2018/9/1
期刊
The Lancet Respiratory Medicine
卷号
6
期号
9
页码范围
691-698
出版商
Elsevier
简介
Background
Precision medicine approaches that target patients on the basis of disease subtype have transformed treatment approaches to cancer, asthma, and other heterogeneous syndromes. Two distinct subphenotypes of acute respiratory distress syndrome (ARDS) have been identified in three US-based clinical trials, and these subphenotypes respond differently to positive end-expiratory pressure and fluid management. We aimed to investigate whether these subphenotypes exist in non-US patient populations and respond differently to pharmacotherapies.
Methods
HARP-2 was a multicentre, randomised controlled trial of simvastatin (80 mg) versus placebo done in general intensive care units (ICUs) at 40 hospitals in the UK and Ireland within 48 h of onset of ARDS. The primary outcome was ventilator-free days, and secondary outcomes included non-pulmonary organ failure-free days and mortality. In a …
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CS Calfee, KL Delucchi, P Sinha, MA Matthay… - The Lancet Respiratory Medicine, 2018