作者
Hugo JWL Aerts, Angela AW van Baardwijk, Steven F Petit, Claudia Offermann, Judith van Loon, Ruud Houben, Anne-Marie C Dingemans, Rinus Wanders, Liesbeth Boersma, Jacques Borger, Gerben Bootsma, Wiel Geraedts, Cordula Pitz, Jean Simons, Bradly G Wouters, Michel Oellers, Philippe Lambin, Geert Bosmans, Andre LAJ Dekker, Dirk De Ruysscher
发表日期
2009/6/1
期刊
Radiotherapy and oncology
卷号
91
期号
3
页码范围
386-392
出版商
Elsevier
简介
BACKGROUND AND PURPOSE
Non-small cell lung cancer (NSCLC) tumours are mostly heterogeneous. We hypothesized that areas within the tumour with a high pre-radiation 18F-deoxyglucose (FDG) uptake, could identify residual metabolic-active areas, ultimately enabling selective-boosting of tumour sub-volumes.
MATERIAL AND METHODS
Fifty-five patients with inoperable stage I–III NSCLC treated with chemo-radiation or with radiotherapy alone were included. For each patient one pre-radiotherapy and one post-radiotherapy FDG-PET-CT scans were available. Twenty-two patients showing persistent FDG uptake in the primary tumour after radiotherapy were analyzed. Overlap fractions (OFs) were calculated between standardized uptake value (SUV) threshold-based auto-delineations on the pre- and post-radiotherapy scan.
RESULTS
Patients with residual metabolic-active areas within the tumour had a …
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