作者
Anastasiya G Trenova, Georgi S Slavov, Milena N Draganova-Filipova, Nonka G Mateva, Mariya G Manova, Lyuba D Miteva, Spaska A Stanilova
发表日期
2018/3/4
期刊
Neurological research
卷号
40
期号
3
页码范围
153-159
出版商
Taylor & Francis
简介
Multiple sclerosis (MS) is associated with cytokine imbalance and high rate (40–70%) of cognitive impairment.
The objective of this study is to investigate the relationship between serum concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-17A, IL-18, IL-10, and cognitive performance in patients with relapsing-remitting MS (RRMS).
Methods
The study comprised 159 patients with RRMS (mean age 40.08 ± 8.48 years) in remission phase and 86 age-, gender-, and education-matched healthy controls. Paced Auditory Serial Addition Test (PASAT), Symbol Digit Modalities test (SDMT), and Isaacs test were used for assessment of working memory, attention, visuo-perceptual abilities, information processing speed, and executive functions. Serum cytokine concentrations were measured by enzyme-linked immunosorbent assay (ELISA).
Results
Patients had significantly increased serum concentrations of TNF …
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AG Trenova, GS Slavov, MN Draganova-Filipova… - Neurological research, 2018