作者
Peiyun Li, Chunrong Zhong, Shuzhen Li, Taoping Sun, Hao Huang, Xi Chen, Yalun Zhu, Xiaoli Hu, Xiaobo Peng, Xu Zhang, Wei Bao, Zhilei Shan, Jinquan Cheng, Frank B Hu, Nianhong Yang, Liegang Liu
发表日期
2018/9/1
期刊
The American journal of clinical nutrition
卷号
108
期号
3
页码范围
603-610
出版商
Elsevier
简介
Background
The microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) has been reported as a novel and independent risk factor for the development of cardiovascular and metabolic diseases, but the association with gestational diabetes mellitus (GDM) remains unclear.
Objective
The aim of this study was to investigate the association between plasma TMAO concentration and GDM in a 2-phase study.
Design
A 2-phase design was used in the current study. An initial phase included 866 participants (433 GDM cases and 433 matched controls) with fasting blood samples collected at the time of GDM screening (24–32 wk of gestation). An independent-phase study, with 276 GDM cases and 552 matched controls who provided fasting blood samples before 20 wk of gestation and who had GDM screened during 24–32 wk of gestation, was nested within a prospective cohort study. These 2 studies were both …
学术搜索中的文章
P Li, C Zhong, S Li, T Sun, H Huang, X Chen, Y Zhu… - The American journal of clinical nutrition, 2018
