作者
Zhiqiang Wang, Graeme Jones, Tania Winzenberg, Guoqi Cai, Laura L Laslett, Dawn Aitken, Ingrid Hopper, Ambrish Singh, Robert Jones, Jurgen Fripp, Changhai Ding, Benny Antony
发表日期
2020/12/1
期刊
Annals of internal medicine
卷号
173
期号
11
页码范围
861-869
出版商
American College of Physicians
简介
Background
Current pharmacologic therapies for patients with osteoarthritis are suboptimal.
Objective
To determine the efficacy of Curcuma longa extract (CL) for reducing knee symptoms and effusion–synovitis in patients with symptomatic knee osteoarthritis and knee effusion–synovitis.
Design
Randomized, double-blind, placebo-controlled trial. (Australian New Zealand Clinical Trials Registry: ACTRN12618000080224)
Setting
Single-center study with patients from southern Tasmania, Australia.
Participants
70 participants with symptomatic knee osteoarthritis and ultrasonography-defined effusion–synovitis.
Intervention
2 capsules of CL (n = 36) or matched placebo (n = 34) per day for 12 weeks.
Measurements …
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Z Wang, G Jones, T Winzenberg, G Cai, LL Laslett… - Annals of internal medicine, 2020