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Human skin is one of the most complex body organs that functions as a physical barrier against water loss and environmental stressors that include UV radiation, reactive oxygen species, pathogens, chemicals and physical agents. Skin texture may undergo ageing, fragility of the dermal layer, thinning, laxity, enlarged pores, dryness, fine lines, and wrinkles as a result of chronic exposure to intrinsic and extrinsic destructive factors. This leads to the growing importance of the cosmetic industry. Therefore, there is a need to investigate harmless and efficient natural raw ingredients, and cyanobacteria-derived compounds have the potential to cope with this challenge. Cyanobacteria are important metabolite sources, which can be used to fight against skin-related problems. Cyanobacteria are morphologically diverse photosynthetic prokaryotes that are broadly distributed in both terrestrial and aquatic environments …