作者
G Joshi-Tope, Marc Gillespie, Imre Vastrik, Peter D'Eustachio, Esther Schmidt, Bernard de Bono, Bijay Jassal, Gopal R Gopinath, GR Wu, Lisa Matthews, Suzanna Lewis, Ewan Birney, Lincoln Stein
发表日期
2005/1/1
期刊
Nucleic acids research
卷号
33
期号
suppl_1
页码范围
D428-D432
出版商
Oxford University Press
简介
Reactome, located at http://www.reactome.org is a curated, peer-reviewed resource of human biological processes. Given the genetic makeup of an organism, the complete set of possible reactions constitutes its reactome. The basic unit of the Reactome database is a reaction; reactions are then grouped into causal chains to form pathways. The Reactome data model allows us to represent many diverse processes in the human system, including the pathways of intermediary metabolism, regulatory pathways, and signal transduction, and high-level processes, such as the cell cycle. Reactome provides a qualitative framework, on which quantitative data can be superimposed. Tools have been developed to facilitate custom data entry and annotation by expert biologists, and to allow visualization and exploration of the finished dataset as an interactive process map. Although our primary curational domain is pathways …
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G Joshi-Tope, M Gillespie, I Vastrik, P D'Eustachio… - Nucleic acids research, 2005