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A novel biocompatible polysaccharidebased selfhealing hydrogel, CEClOSAlADH hydrogel (“l” means “linkedby”), is developed by exploiting the dynamic reaction of Ncarboxyethyl chitosan (CEC) and adipic acid dihydrazide (ADH) with oxidized sodium alginate (OSA). The selfhealing ability, as demonstrated by rheological recovery, macroscopic observation, and beamshaped strain compression measurement, is attributed to the coexistence of dynamic imine and acylhydrazone bonds in the hydrogel networks. The CEClOSAlADH hydrogel shows excellent selfhealing ability under physiological conditions with a high healing efficiency (up to 95%) without need for any external stimuli. In addition, the CEClOSAlADH hydrogel exhibits good cytocompatibility and cell release as demonstrated by threedimensional cell encapsulation. With these superior properties, the developed hydrogel holds …