作者
Yong Chen, Quan Fang, Zilong Wang, Jennifer Y Zhang, Amanda S MacLeod, Russell P Hall, Wolfgang B Liedtke
发表日期
2016/5/6
期刊
Journal of Biological Chemistry
卷号
291
期号
19
页码范围
10252-10262
出版商
Elsevier
简介
TRPV4 ion channels function in epidermal keratinocytes and in innervating sensory neurons; however, the contribution of the channel in either cell to neurosensory function remains to be elucidated. We recently reported TRPV4 as a critical component of the keratinocyte machinery that responds to ultraviolet B (UVB) and functions critically to convert the keratinocyte into a pain-generator cell after excess UVB exposure. One key mechanism in keratinocytes was increased expression and secretion of endothelin-1, which is also a known pruritogen. Here we address the question of whether TRPV4 in skin keratinocytes functions in itch, as a particular form of "forefront" signaling in non-neural cells. Our results support this novel concept based on attenuated scratching behavior in response to histaminergic (histamine, compound 48/80, endothelin-1), not non-histaminergic (chloroquine) pruritogens in Trpv4 keratinocyte …
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Y Chen, Q Fang, Z Wang, JY Zhang, AS MacLeod… - Journal of Biological Chemistry, 2016