作者
Whitney W Stevens, Christopher J Ocampo, Sergejs Berdnikovs, Masafumi Sakashita, Mahboobeh Mahdavinia, Lydia Suh, Tetsuji Takabayashi, James E Norton, Kathryn E Hulse, David B Conley, Rakesh K Chandra, Bruce K Tan, Anju T Peters, Leslie C Grammer III, Atsushi Kato, Kathleen E Harris, Roderick G Carter, Shigeharu Fujieda, Robert C Kern, Robert P Schleimer
发表日期
2015/9/15
期刊
American journal of respiratory and critical care medicine
卷号
192
期号
6
页码范围
682-694
出版商
American Thoracic Society
简介
Rationale: The mechanisms that underlie the pathogenesis of chronic rhinosinusitis without nasal polyps (CRSsNP), chronic rhinosinusitis with nasal polyps (CRSwNP), and aspirin-exacerbated respiratory disease (AERD) are not clear.
Objectives: To first evaluate the inflammatory profiles of CRSsNP and CRSwNP tissues and then to investigate whether clinical differences observed between CRSwNP and AERD are in part secondary to differences in inflammatory mediator expression within nasal polyp (NP) tissues.
Methods: Expression levels of numerous inflammatory mediators were determined by quantitative real-time polymerase chain reaction, ELISA, and multiplex immunoassay.
Measurements and Main Results: CRSwNP NP had increased levels of type 2 mediators, including IL-5 (P < 0.001), IL-13 (P < 0.001), eotaxin-2 (P < 0.001), and monocyte chemoattractant protein (MCP)-4 (P < 0.01 …
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WW Stevens, CJ Ocampo, S Berdnikovs, M Sakashita… - American journal of respiratory and critical care …, 2015