作者
Tetsuji Takabayashi, Atsushi Kato, Anju T Peters, Kathryn E Hulse, Lydia A Suh, Roderick Carter, James Norton, Leslie C Grammer, Seong H Cho, Bruce K Tan, Rakesh K Chandra, David B Conley, Robert C Kern, Shigeharu Fujieda, Robert P Schleimer
发表日期
2013/1/1
期刊
American journal of respiratory and critical care medicine
卷号
187
期号
1
页码范围
49-57
出版商
American Thoracic Society
简介
Rationale: Nasal polyps (NPs) are characterized by intense edema or formation of pseudocysts filled with plasma proteins, mainly albumin. However, the mechanisms underlying NP retention of plasma proteins in their submucosa remain unclear.
Objectives: We hypothesized that formation of a fibrin mesh retains plasma proteins in NPs. We assessed the fibrin deposition and expression of the components of the fibrinolytic system in patients with chronic rhinosinusitis (CRS).
Methods: We assessed fibrin deposition in nasal tissue from patients with CRS and control subjects by means of immunofluorescence. Fibrinolytic components, d-dimer, and plasminogen activators were measured using ELISA, real-time PCR, and immunohistochemistry. We also performed gene expression and protein quantification analysis in cultured airway epithelial cells.
Measurements and Main Results: Immunofluorescence data showed …
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T Takabayashi, A Kato, AT Peters, KE Hulse, LA Suh… - American journal of respiratory and critical care …, 2013