查看文章

Multiple myeloma (MM) is a plasma cell malignancy that accounts for approximately 10% of all hematologic malignancies [1]. Poor prognosis in MM is associated with chromosomal aberrations such as gain (1q), del (17p) and translocation t (4; 14)[2]. However, the molecular mechanisms by which adverse cytogenetics impact on the course of the disease remains incompletely understood. In a recent study, the small nucleolar RNA (snoRNA) SCARNA22 was found to be overexpressed in MM patients with t (4; 14) and was associated with reduced survival [3]. The snoRNAs are non-coding RNAs of 60–300 nucleotides [4], which can be divided into two classes: the C/D box (SNORDs), which guide 2′-O-methylation, and the H/ACA box snoRNAs (SNORAs), which direct pseudouridylation [5], both playing a regulatory role in ribosome biogenesis. Emerging evidence suggests that snoRNAs contribute to oncogenesis …