作者
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A Chen, Russell T Shinohara, Dina Jacobs, Roy N Alcalay, Thomas F Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
发表日期
2022/8/1
期刊
EBioMedicine
卷号
82
页码范围
104179
出版商
Elsevier
简介
Background
Immunosenescence (ISC) describes age-related changes in immune-system composition and function. Multiple sclerosis (MS) is a lifelong inflammatory condition involving effector and regulatory T-cell imbalance, yet little is known about T-cell ISC in MS. We examined age-associated changes in circulating T cells in MS compared to normal controls (NC).
Methods
Forty untreated MS (Mean Age 43·3, Range 18–72) and 49 NC (Mean Age 48·6, Range 20–84) without inflammatory conditions were included in cross-sectional design. T-cell subsets were phenotypically and functionally characterized using validated multiparametric flow cytometry. Their aging trajectories, and differences between MS and NC, were determined using linear mixed-effects models.
Findings
MS patients demonstrated early and persistent redistribution of naïve and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell …
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L Zuroff, A Rezk, K Shinoda, DA Espinoza, Y Elyahu… - EBioMedicine, 2022