作者
Prudence Tettey, Steve Simpson Jr, Bruce Taylor, Leigh Blizzard, Anne-Louise Ponsonby, Terence Dwyer, Karam Kostner, Ingrid van der Mei
发表日期
2014/11
期刊
Multiple Sclerosis Journal
卷号
20
期号
13
页码范围
1737-1744
出版商
Sage Publications
简介
Background
There is accumulating data suggesting an association between serum lipids, apolipoproteins and disability in multiple sclerosis (MS).
Objectives
To investigate the associations between serum lipids, apolipoproteins and disability in MS.
Methods
A cohort of 178 participants with clinically-definite MS in southern Tasmania, Australia were prospectively followed from 2002 – 2005, and serum samples were obtained at study entry and at each biannual review, to measure lipid profile and apolipoprotein levels. Associations with disability and annual change in disability were evaluated using linear regression and multilevel mixed-effects linear regression.
Results
In the unadjusted analyses, nearly all lipid-related variables were positively associated with Expanded Disability Status Scale (EDSS). After adjustment for confounders, total cholesterol (TC) (p = 0.037), apolipoprotein B (ApoB) (p = 0.003), and the …
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P Tettey, S Simpson Jr, B Taylor, L Blizzard… - Multiple Sclerosis Journal, 2014