作者
Benjamin D Medoff, Alain Sauty, Andrew M Tager, James A Maclean, R Neal Smith, Anuja Mathew, Jennifer H Dufour, Andrew D Luster
发表日期
2002/5/15
期刊
The Journal of Immunology
卷号
168
期号
10
页码范围
5278-5286
出版商
American Association of Immunologists
简介
Allergic asthma is an inflammatory disease of the airways characterized by eosinophilic inflammation and airway hyper-reactivity. Cytokines and chemokines specific for Th2-type inflammation predominate in asthma and in animal models of this disease. The role of Th1-type inflammatory mediators in asthma remains controversial. IFN-γ-inducible protein 10 (IP-10; CXCL10) is an IFN-γ-inducible chemokine that preferentially attracts activated Th1 lymphocytes. IP-10 is up-regulated in the airways of asthmatics, but its function in asthma is unclear. To investigate the role of IP-10 in allergic airway disease, we examined the expression of IP-10 in a murine model of asthma and the effects of overexpression and deletion of IP-10 in this model using IP-10-transgenic and IP-10-deficient mice. Our experiments demonstrate that IP-10 is up-regulated in the lung after allergen challenge. Mice that overexpress IP-10 in the lung …
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BD Medoff, A Sauty, AM Tager, JA Maclean, RN Smith… - The Journal of Immunology, 2002