发明者
Philipp Hadwiger, Torsten Hoffmann, Eric A Kitas, Peter Mohr, Ingo Roehl, Linda Valis, David B Rozema, David L Lewis, Darren H Wakefield
发表日期
2016/2/2
专利局
US
专利号
9249179
专利申请号
13327271
简介
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers.
学术搜索中的文章
P Hadwiger, T Hoffmann, EA Kitas, P Mohr, I Roehl… - US Patent 9,249,179, 2016