作者
Niels Voigt, Adina Friedrich, Manja Bock, Erich Wettwer, Torsten Christ, Michael Knaut, Ruth H Strasser, Ursula Ravens, Dobromir Dobrev
发表日期
2007/6/1
期刊
Cardiovascular research
卷号
74
期号
3
页码范围
426-437
出版商
Elsevier Science
简介
Objective: In chronic atrial fibrillation (cAF) the potassium current IK,ACh develops agonist-independent constitutive activity. We hypothesized that abnormal phosphorylation-dependent regulation underlies the constitutive IK,ACh activity.
Methods: We used voltage-clamp technique and biochemical assays to study IK,ACh regulation in atrial appendages from 61 sinus rhythm (SR), 11 paroxysmal AF (pAF), and 33 cAF patients.
Results: Compared to SR basal current was higher in cAF only, whereas the muscarinic receptor (2 μmol/L carbachol)-activated IK,ACh was smaller in pAF and cAF. In pAF the selective IK,ACh blocker tertiapin abolished the muscarinic receptor-activated IK,ACh but excluded agonist-independent constitutive IK,ACh activity. Blockade of type-2A phosphatase and the subsequent shift to increased muscarinic receptor phosphorylation (and inactivation) reduced …
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N Voigt, A Friedrich, M Bock, E Wettwer, T Christ… - Cardiovascular research, 2007
