作者
Rajib Hossain, Cristina Quispe, Jesús Herrera-Bravo, Jorge F Beltrán, Muhammad Torequl Islam, Shabnum Shaheen, Natália Cruz-Martins, Miquel Martorell, Manoj Kumar, Javad Sharifi-Rad, Fethi Ahmet Ozdemir, William N Setzer, Mohammed M Alshehri, Daniela Calina, William C Cho
发表日期
2022
来源
Oxidative Medicine and Cellular Longevity
卷号
2022
期号
1
页码范围
3079577
出版商
Hindawi
简介
Andrographolide (ANDRO), a bitter diterpene lactone found in Andrographis paniculata (Burm.f.) Nees, possesses several biological effects such as antioxidant, anti‐inflammatory, and organo‐protective effects. Scientific reports suggest that it also has neuroprotective capacity in various test systems. The purpose of this review was to synthesize the neuropharmacological properties of ANDRO and highlight the molecular mechanisms of action that highlight these activities. A careful search was done in PubMed and Google Scholar databases using specific keywords. Findings suggest that ANDRO possess neuroprotective, analgesic, and antifatigue effects. Prominent effects were stated on neuro‐inflammation, cerebral ischemia, Alzheimer’s and Parkinson’s diseases, multiple sclerosis, and brain cancer in mice and rats. Furthermore, ANDRO and its derivatives can enhance memory and learning capacity in …
学术搜索中的文章
R Hossain, C Quispe, J Herrera-Bravo, JF Beltrán… - Oxidative Medicine and Cellular Longevity, 2022