作者
Chao Dai, Jonathan P Rennhack, Taylor E Arnoff, Maneesha Thaker, Scott T Younger, John G Doench, August Yue Huang, Annan Yang, Andrew J Aguirre, Belinda Wang, Evan Mun, Joyce T O’Connell, Ying Huang, Katherine Labella, Jessica A Talamas, Ji Li, Nina Ilic, Justin Hwang, Andrew L Hong, Andrew O Giacomelli, Ole Gjoerup, David E Root, William C Hahn
发表日期
2021/7/27
期刊
Cell reports
卷号
36
期号
4
出版商
Elsevier
简介
Metastasis is a complex and poorly understood process. In pancreatic cancer, loss of the transforming growth factor (TGF)-β/BMP effector SMAD4 is correlated with changes in altered histopathological transitions, metastatic disease, and poor prognosis. In this study, we use isogenic cancer cell lines to identify SMAD4 regulated genes that contribute to the development of metastatic colonization. We perform an in vivo screen identifying FOSL1 as both a SMAD4 target and sufficient to drive colonization to the lung. The targeting of these genes early in treatment may provide a therapeutic benefit.
学术搜索中的文章
C Dai, JP Rennhack, TE Arnoff, M Thaker, ST Younger… - Cell reports, 2021