作者
Reza Jahani, Faraz Mojab, Arash Mahboubi, Azadeh Nasiri, Armin Tahamtani, Mehrdad Faizi
发表日期
2019
期刊
Iranian Journal of Pharmaceutical Research: IJPR
卷号
18
期号
3
页码范围
1456
出版商
Brieflands
简介
Antidepressant-like activity of T. kotschyanus has been recently reported by scientists but insufficient attention has been so far devoted to T. kotschyanus, and there is a lack of information on the other neurobehavioral effects and side effects of this species. In the current study, the anticonvulsant, anxiolytic, and sedative-hypnotic, effects of Thymus kotschyanus extract on male NMRI mice were evaluated using pentylenetetrazole, maximal electroshock, elevated plus maze, and pentobarbital-induced sleeping tests. Since phenolic compounds and flavonoids have main roles in pharmacological effects of most plant extracts, the phenolic and flavonoid contents of the extract were measured with Folin-Ciocalteu and AlCl 3 reagents. Acute toxicity, passive avoidance, and open field tests were carried out to assess the toxicity of the extract. To find out the possible mechanism of action, flumazenil as the specific GABA A …
引用总数
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