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Infection and lack of angiogenesis are considered to be the main factors slowing the healing process in chronic wounds. To address these challenges, bioactive, multi-functional wound dressings have received a lot of attention. A 3D-printed carboxymethyl chitosan scaffold loaded with Tacrolimus (TAC-CMC) was introduced and tested as a potential bioactive dressing for chronic wound healing. Following topographical and physical characterization of the wound dressings, the release profile of Tacrolimus from the TAC-CMC scaffold was investigated. In vitro evaluation revealed that both carboxymethyl chitosan scaffold (CMC) and TAC-CMC scaffolds were biocompatible, but only TAC-CMC causing an increase in the secretion of vascular endothelial growth factor (VEGF) from fibroblasts. Disk diffusion test of the fabricated scaffolds demonstrated a significant antibacterial activity of TAC-CMC scaffold against both E …