查看文章

Serotonin (5-HT)_1A and 5-HT_1B receptors have been implicated in the incidence and treatment of depression in part through the examination of animals lacking these receptors. Although these receptors have been repeatedly implicated in ingestive behavior there is little information about how 5-HT_1A and 5-HT_1B receptor mutant mice react to solutions of varying palatability. In the present experiment male and female 5-HT_1A and 5-HT_1B mutant and wild-type mice were presented with increasing concentrations of sucrose using a two-bottle choice procedure. In addition fasting blood glucose levels were assessed. Both male and female 5-HT_1B mutant mice drank more sucrose than WT mice but also consumed more water. Female, but not male, 5-HT_1A mutant mice similarly showed increased sucrose consumption, but did not demonstrate increased consumption of water. In addition, the pattern of increased …