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Currently, limited data exist as to long‐term disease‐specific outcomes after endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS). In this report, we present outcomes data collected over 5 years in a large prospective cohort of patients who underwent surgical treatment for CRS.

Patients who completed the 22‐item Sino‐Nasal Outcome Test (SNOT‐22) before ESS were asked to complete the same survey at yearly intervals for 5 years thereafter. The impact of patients’ demographics and clinical characteristics on clinical outcome was measured using mixed effects modeling for univariate and multivariable analysis. Multivariable logistic regression threshold analyses were also performed.

Among the 925 patients enrolled in the study, the SNOT‐22 was completed after ESS by 641 patients (69.3%) at 1 year and 338 patients (36.5%) at 5 years. The mean preoperative SNOT …