作者
Ashton E Lehmann, George A Scangas, Regan W Bergmark, Edward El Rassi, Konstantina M Stankovic, Ralph Metson
发表日期
2019/6
来源
Otolaryngology–Head and Neck Surgery
卷号
160
期号
6
页码范围
965-973
出版商
SAGE Publications
简介
Objective
To provide a comprehensive overview of the emerging role of periostin, an extracellular matrix protein, as a key component in the development, diagnosis, and treatment of patients with chronic rhinosinusitis.
Data Sources
Medline database.
Review Methods
A state of the art review was performed targeting English-language studies investigating the role of periostin in cardiopulmonary, neoplastic, and inflammatory diseases, with emphasis on recent advances in the study of periostin in chronic rhinosinusitis.
Conclusions
Periostin has emerged as a novel biomarker and therapeutic target for numerous human pathologies, including cardiac, pulmonary, and neoplastic disease. The upregulation of periostin in chronic rhinosinusitis suggests the potential for similar roles among patients with sinonasal disease.
Implications for Practice
Chronic rhinosinusitis is a widespread disease with major clinical and societal …
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AE Lehmann, GA Scangas, RW Bergmark, E El Rassi… - Otolaryngology–Head and Neck Surgery, 2019