作者
Alfonso Fiorelli, Floriana Morgillo, Morena Fasano, Giovanni Vicidomini, Vincenzo Giuseppe Di Crescenzo, Marina Di Domenico, Marina Accardo, Mario Santini
发表日期
2013/3/1
期刊
Interactive cardiovascular and thoracic surgery
卷号
16
期号
3
页码范围
263-269
出版商
Oxford University Press
简介
OBJECTIVES
Our aim was to determine the diagnostic value of the matrix metalloproteinase-9/vascular endothelial grow factor receptor-1 pathway in differentiating pleural effusions (PE) of varying origin.
METHODS
In the last two years, 55 consecutive patients with exudative PE have been enrolled. In all patients, we measured PE levels of vascular endothelial grow factor receptor-1 (VEGFR-1) in soluble form, through enzyme-linked immunosorbent assay (ELISA) (results expressed in pg/ml) and western blot, and of matrix metalloproteinase-9 (MMP-9), through ELISA (results expressed in ng/ml). The values recorded were then statistically compared with the etiologic diagnosis of the PEs.
RESULTS
Between the PEs analysed, 40 were found to be malignant and 15 to be benign. VEGFR-1 in soluble form (sVEGFR-1) was significantly higher in malignant …
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A Fiorelli, F Morgillo, M Fasano, G Vicidomini… - Interactive cardiovascular and thoracic surgery, 2013